The Difference Between Trending Skin Boosters Rejuran (PN) and Salmon Injection (PDRN) and Their Effects on Scars at MeSo MedSpa Today’s main focus is on Polydeoxyribonucleotide (PDRN) and Polynucleotide (PN). PDRN may not be well known to everyone, but it’s been widely used by healthcare professionals for quite some time. It’s primarily used to accelerate the wound healing process, but lately, it’s been used for a variety of other purposes. Rejuran, I’m Sure You’ve Heard of It? PDRN Rejuran , a representative form of PN , is already extremely popular. As a leading skin booster in recent years, it’s been widely discussed on social media for its benefits on pores, skin elasticity, fine lines, and dryness (also known for improving the skin barrier). You’ve probably come across plenty of posts about its price, benefits, and how it works. But today, I’d like to take a different approach. Rejuran In addition to addressing issues like fine lines and dryness, Rejuran has been used quite frequently for scars, including those that are still healing or immature (such as acne scars in the process of healing). So, let’s take a closer look at the differences between Polynucleotides ( PN ), found in Rejuran , and Polydeoxyribonucleotides ( PDRN ), which has been used for scar treatments and wound healing for quite some time, and explore how both of them work for scars. What Are PDRN (Salmon Injection) and PN (Rejuran), and What’s the Difference? PDRN and PN are similar DNA-derived substances that have been recognized for their roles in wound healing and skin regeneration since the 1990s. These substances are both extracted from the reproductive cells of salmon. PDRN is extracted from the sperm (seminal fluid) of salmon. PN is extracted from the testes of salmon. The Difference and Effects of PN and PDRN Marques C, Porcello A, Cerrano M, Hadjab F, Chemali M, Lourenço K, Hadjab B, Raffoul W, Applegate LA, Laurent AE. From Polydeoxyribonucleotides (PDRNs) to Polynucleotides (PNs): Bridging the Gap Between Scientific Definitions, Molecular Insights, and Clinical Applications of Multifunctional Biomolecules. Biomolecules. 2025 Jan 19;15(1):148. PDRN and PN are made up of DNA fragments that form high-molecular compounds, typically ranging from 50–1500kDa, though more recent studies have found fragments with sizes ranging from 1kDa to 10,000kDa. Both PDRN and PN stimulate the A2A receptor in fibroblasts, which in turn triggers the production of cAMP, leading to the activation of Protein Kinase A (PKA). PKA directly affects cell growth, survival, and differentiation, contributing to tissue regeneration and wound healing. These effects have made PDRN and PN widely used in skin treatments. In Rejuran , 2ml contains 40mg of PN . To go into more detail about the types of Rejuran : Rejuran Healer , Rejuran Eye , and Rejuran S all contain the same amount of PN per ml, but they differ in viscosity. Rejuran HB Plus contains half the amount of PN per ml, but it also includes hyaluronic acid and anesthetics. PN is a larger molecule compared to PDRN , and it tends to bond more easily with water molecules, which increases its moisturizing effects. Additionally, the larger size of PN allows it to act as a supporting structure, much like a filler, which is a key difference between PN and PDRN . PN also remains in the skin for a longer period of time, providing prolonged effects. Effects of PDRN and PN on Scars As discussed earlier, when PDRN binds to the A2A receptor, cAMP levels increase, which leads to the activation of PKA. This activation directly impacts cell growth, survival, and differentiation, ultimately promoting tissue regeneration and wound healing. Therefore, PDRN is particularly effective for scars that are not fully matured yet. This includes red acne scars, fresh wound scars, and burn scars. PN (think of Rejuran ) acts similarly to a filler and has long-lasting effects. It also creates a more humid environment, which makes it especially effective for scars. This is why PN has become more popular for scar treatment recently, with more studies available on its use compared to PDRN . For example, several studies have shown improvements in scar texture and redness (erythema) after just 2 to 3 treatments with Rejuran S . The role of PN , as a larger molecule that can act like a filler, is particularly useful for atrophic (sunken) acne scars. It provides volume and supports the skin in the healing process, while also maintaining its effect for a longer period. Additionally, PDRN has anti-aging benefits such as: Improving skin texture Increasing DNA synthesis for wound healing and regeneration Inhibiting tyrosinase (helping with pigmentation) Improving hair quality Recently, Rejuran ’s popularity has been growing rapidly, and I believe the reason behind its success is clear. It has both theoretical backing and clear, visible results, with safety being another significant factor. I recommend that, rather than focusing only on interval spacing or embossing, you should understand the potential effects and make sure you know exactly what results you’re aiming for when receiving the treatment. Rejuran is not only effective for moisturizing, pores, fine lines, and redness but also works wonders for scars. I hope it becomes more widely recognized as a skin booster that’s effective for scars too! :) About Us Me:SO Medspa Opening Hours: Monday — Friday : 10:00 AM — 7:00 PM Saturday : 10:00 AM — 7:00 PM Sunday : Closed Address: 20321 SW Acacia St, Suite 150, Newport Beach, OC, CA 92660, USA 5585 E. Santa Ana Canyon Rd. Anaheim Hills, CA 92807 Phone: 949–617–1221 714–294–2113 Follow Us On: Homepage | Instagram | Facebook

Hello, this is MeSO MedSpa. One common treatment that delivers heat to the skin is laser lifting. So, if we’re in a hot environment, can heat lift our skin? Today, I’m going to explain the difference between good heat and bad heat for your skin. Understanding this can help with anti-aging, and it will also provide you with key information to make your skin healthier. Stay with me! Good Heat vs Bad Heat: The Criteria Heat on your skin can be like a double-edged sword, or the two sides of a coin. It can be beneficial or harmful. So, naturally, we want to avoid the harmful heat and only choose the good. There are two main criteria for distinguishing good from bad heat: (1) Depth of Heat (2) Temperature of Heat Let’s dive into this in more detail. Good Heat: Laser Lifting Treatments like Ulthera, Thermage, and Oligio X, Micro-Lifting at MeSO MedSpa all work by applying heat to different layers of the skin to lift and tighten it. The heat causes skin tissue to contract and stimulates fibroblasts to increase collagen production. a. Depth of Heat Dermis Layer All lifting treatments primarily stimulate fibroblasts in the dermis to boost collagen production and contract existing collagen. This is the ideal depth for optimal results. Fat Tissue Treatments like Ulthera and Micro-Lifting use heat to target the fat layer to help shrink it. SMAS Layer High-intensity focused ultrasound (HIFU) treatments like Ulthera work on the SMAS layer, providing a powerful lifting effect. The common feature of good heat for the skin is that it should reach layers deeper than the epidermis. The epidermis doesn’t respond well to heat; it can dry out the skin and cause burns if the temperature exceeds 44°C. The key to lifting lasers at MeSO MedSpa is to apply heat to deeper layers while protecting the epidermis. This is why a cooling system that minimizes heat exposure to the epidermis is critical. b. Temperature of Heat Most lifting lasers generate heat at temperatures between 43–70°C. This range is ideal for stimulating collagen contraction and fibroblast activity. At the same time, this temperature does not activate MMP (Matrix Metalloproteinase) enzymes, which are responsible for breaking down collagen. These enzymes are primarily activated at temperatures between 37–40°C, so maintaining a temperature between 43–70°C helps increase collagen production without promoting its breakdown. Bad Heat: Skin Aging Bad heat for the skin comes from environmental factors like sunlight and saunas, which raise skin temperature. Here are five harmful effects that result from this type of heat: a. Reduced Moisture → Dry Skin As skin temperature rises, moisture evaporates more quickly, leading to skin dryness. Although it feels humid in the summer, the skin can still become dry. b. Dry Skin → Increased Sebum When skin is dry, it produces more sebum to prevent further moisture loss. This disrupts the skin’s moisture-oil balance. c. Increased Sebum → Acne and Breakouts Excess sebum can clog pores and lead to acne or other skin issues. When sebum accumulates, it can cause folliculitis and other skin problems. d. Decreased Collagen → Loss of Elasticity, More Wrinkles When skin temperature rises above 37°C, MMP enzymes break down damaged collagen and even healthy collagen. This process leads to a decrease in collagen and results in less skin elasticity and more wrinkles. e. Blood Vessel Expansion → Redness To cool down the skin, blood vessels expand to release heat. This can cause redness. Repeated episodes can cause the blood vessels to stay dilated, resulting in persistent redness. Analyzing Bad Heat Using Two Criteria a. Depth of Heat Heat from external environments penetrates the outermost layer of the skin, the epidermis. Unlike deeper layers, the epidermis doesn’t handle heat well; it evaporates moisture and can cause burns at temperatures above 44°C. b. Temperature of Heat External heat typically raises skin temperature to around 37–42°C, but it cannot exceed 44°C, as that’s when burns occur. This range of heat activates MMP enzymes, accelerating skin aging. Now, you should be able to distinguish between good and bad heat for your skin. Good heat should protect the epidermis while delivering heat to the deeper layers, which is why lasers at MeSO MedSpa are effective. You should avoid thinking that any heat, even without lasers, can provide lifting effects without risking harmful heat exposure. We hope the information we shared helps protect your precious skin! If you have any questions, feel free to contact us at MeSO MedSpa. We’ll be back with another exciting topic next time! About Us Me:SO Medspa Opening Hours: Monday — Friday : 10:00 AM — 7:00 PM Saturday : 10:00 AM — 7:00 PM Sunday : Closed Address: 20321 SW Acacia St, Suite 150, Newport Beach, OC, CA 92660, USA 5585 E. Santa Ana Canyon Rd. Anaheim Hills, CA 92807 Phone: 949–617–1221 714–294–2113 Follow Us On: Homepage | Instagram | Facebook

Hello, this is MeSO Medspa. Today, let’s talk about the difference between HIFU, the ultrasound lifting treatment, and RF, the radiofrequency lifting treatment — their unique features and how each can transform your skin. Lost firmness in my face… As we age or neglect skincare, we often feel like our facial firmness has declined. On top of that, you may notice deepening nasolabial folds and sagging facial lines in the mirror, which is usually when people start looking up lifting treatments. But the world of lifting treatments can feel overwhelming with so many options. In fact, they can be broadly categorized into two types depending on the energy used: Ultrasound (HIFU) and Radiofrequency (RF) . HIFU, what is ultrasound lifting? HIFU uses high-intensity ultrasound to deliver energy deep into the skin, reaching the SMAS layer (the fascia). Simply put, it works like a magnifying glass focusing sunlight onto one spot to ignite fire. At MeSO, our Micro Lifting treatment works on this principle. The ultrasound energy generates high heat (42–45℃) deep within the skin, causing collagen contraction and fat cell apoptosis, which helps reduce sagging tissue. Then what are the mechanisms and effects? First, the heat restructures collagen. As the skin attempts to repair the “damage,” new collagen production is stimulated. Second, it triggers apoptosis (programmed cell death) of fat cells, reducing excess fat in areas like sagging cheeks or double chin. That’s why HIFU is ideal for facial contour lifting — for those who want a defined V-line, to tighten sagging cheeks, or to smooth out fine lines around the eyes and jawline. Then what is RF, radiofrequency lifting? RF uses radiofrequency energy to gently deliver heat into the skin via electrical currents. It feels like placing a warm compress on your skin, creating a soothing warmth from within. At MeSO, our Oligio X operates on this principle. RF energy evenly penetrates the dermis, producing heat between 40–55℃. Around 45℃, abundant type 1 and type 3 collagen are generated. Mechanism and effects of RF lifting? The heat contracts existing collagen fibers while activating fibroblasts, inducing new collagen production. At the same time, it stimulates hyaluronic acid synthesis, which makes the skin plumper, firmer, and more hydrated. This makes RF ideal for those with overall loss of elasticity, rough skin texture, or enlarged pores. In particular, for patients with little facial fat or thin, sensitive skin, treatments like Oligio X are recommended. Since RF is gentle and safe for delicate skin, more and more people are seeking it out. Patients often report that RF makes their skin feel smoother in texture with noticeable elasticity from deep within. HIFU vs. RF, which treatment is right for me? If you need facial contour lifting or want to tighten sagging lines → HIFU (e.g., Micro Lifting). If your goal is overall elasticity and texture improvement, or if your skin is thin and sensitive → RF (e.g., Oligio X). One important note! HIFU and RF work even better when combined. For example, HIFU sharpens facial contours while RF smooths skin texture, doubling the effect. Since they target different skin layers, combining both treatments often brings higher satisfaction. Rather than asking which treatment is better, the key is choosing the right one based on your skin type and concerns — or combining both for maximum effect. At MeSO, we provide thorough skin assessments and personalized lifting solutions, so feel free to visit us for a consultation anytime. About Us Me:SO Medspa Opening Hours: Monday — Friday : 10:00 AM — 7:00 PM Saturday : 10:00 AM — 7:00 PM Sunday : Closed Address: 20321 SW Acacia St, Suite 150, Newport Beach, OC, CA 92660, USA 5585 E. Santa Ana Canyon Rd. Anaheim Hills, CA 92807 Phone: 949–617–1221 714–294–2113 Follow Us On: Homepage | Instagram | Facebook